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  • Chronic hypertension...

Chronic hypertension treatment in pregnancy improves fetal and maternal outcomes: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-12-30T19:00:56+05:30  |  Updated On 13 Oct 2023 5:23 PM IST
Chronic hypertension treatment in pregnancy improves fetal and maternal outcomes: Study
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Egypt: The use of antihypertensive drug labetalol in pregnant women with chronic hypertension, was associated with higher rates of neonatal hyperbilirubinemia, neonatal hypotension, and higher rates of SGA, suggests a recent study. According to the study, published in the journal Hypertension in Pregnancy, treatment of mild to moderate chronic hypertension during pregnancy is beneficial for reducing both fetal and maternal morbidity.

Mohamed Rezk, Menoufiya University, Shibin Al Kawm, Egypt, and colleagues assessed the fetal and maternal outcome in women with mild to moderate chronic hypertension on antihypertensive drug (methyldopa or labetalol) therapy compared to no medication.

The multicenter randomized clinical study included 486 pregnant women wit mild to moderate chronic hypertension. They were randomized into three groups: methyldopa group (n = 164), labetalol group (n = 160), and control or no medication group (n = 162). They were followed from the beginning of the pregnancy till the end of puerperium to record maternal and fetal outcome.

Key findings of the study include:

  • There was a highly significant difference between treatment groups (methyldopa and labetalol) and control group regarding the development of maternal severe hypertension, development of preeclampsia, renal impairment, presence of ECG changes, placental abruption, and repeated admission to hospital for blood pressure control with higher occurrence in the control (no treatment) group.
  • Neonates in the labetalol group were more prone for the development of small for gestational age (SGA), neonatal hypotension, neonatal hyperbilirubinemia, and admission to NICU than their counterparts in the methyldopa and control groups.
  • The rate of prematurity was significantly higher in the control group than the treatment groups.

"Treatment of mild to moderate chronic hypertension during pregnancy is beneficial in decreasing both maternal and fetal morbidity. The use of labetalol was associated with higher rates of SGA, neonatal hypotension, and neonatal hyperbilirubinemia compared to methyldopa or no medication," concluded the authors.

"Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial," is published in the journal Hypertension in Pregnancy.

DOI: https://www.tandfonline.com/doi/abs/10.1080/10641955.2020.1791902


Hypertension in Pregnancychronic hypertensionantihypertensiveslabetalol
Source : Hypertension in Pregnancy
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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