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Interpregnancy Intervals of 24-29 Months Reduce Preterm Birth Risk, finds study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-03-13T21:00:48+05:30  |  Updated On 14 March 2025 10:51 AM IST
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A new study published in BMC Pregnancy and Childbirth found that the interpregnancy interval (IPI) of 24-29 months decreases the risk of preterm birth, making it a crucial factor to consider in family planning and clinical guidance. This study was conducted by Xueheng and fellow researchers.

Systematic literature search was done in PubMed, Cochrane, Web of Science, and Embase through June 2, 2023. Studies included IPI and preterm birth outcomes data, with quality assessment based on the Newcastle-Ottawa Scale (NOS). A Bayesian network meta-analysis was carried out to establish the relationship between IPI length and risk of preterm birth. The meta-analysis comprised 34 studies involving data from 8,646,679 individuals, one of the largest reviews conducted so far on this issue.

Key Findin

• An IPI of 24-29 months was found to be the ideal interval with the least risk of preterm birth.

• Compared with IPIs of < 5 months, a 24-29 month IPI reduced the risk of preterm birth at:

• Less than 32 weeks of gestation (OR = 0.55; 95% CI: 0.50 - 0.62)

• Preterm birth less than 37 weeks of gestation (OR = 0.61; 95% CI: 0.59 - 0.63)

• Brief IPIs, particularly those of less than 5 months, were linked with a higher risk of preterm birth.

• The results highlight the need for spacing pregnancies to reduce unfavorable birth outcomes.

Intervals of less than 5 months are associated with a high risk of preterm birth, further supporting the importance of adequate counseling and advice for pregnant women. Best IPI guidelines should be incorporated by medical practitioners in prenatal and postnatal care to improve fetal and maternal health outcomes.

The study authors establish that 24-29 months of interpregnancy interval significantly decrease the risk of preterm birth, and it gives very important information for family planning and guidelines on maternal health. Birth spacing should be encouraged by healthcare professionals in order to avoid poor pregnancy outcomes and enhance neonatal well-being.

Reference:

Wen, X., Liang, W., Zhai, J. et al. The association between interpregnancy intervals and preterm birth: a systematic review and meta-analysis. BMC Pregnancy Childbirth 25, 226 (2025). https://doi.org/10.1186/s12884-025-07259-y

BMC Pregnancy and ChildbirthPreterm BirthInterpregnancy IntervalPregnancy SpacingMaternal HealthNeonatal OutcomesFamily Planning
Source : BMC Pregnancy and Childbirth
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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