Radiotherapy in indolent gastroduodenal lymphoma patients tied to diabetes: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-04-05T18:10:13+05:30 | Updated On 5 April 2021 6:10 PM IST

Seoul, Korea: Patients with gastroduodenal indolent lymphoma who receive radiotherapy (RT) are at increased diabetes risk compared to those who do not, finds a recent study in the journal Cancer Research and Treatment.

Jong Yun Baek, Sungkyunkwan University School of Medicine, Seoul, Korea, and colleagues aimed to evaluate the effect of radiotherapy on the risk of diabetes by assessing hemoglobin A1c (HbA1c) levels in gastroduodenal indolent lymphoma patients.

For this purpose, the researchers performed a retrospective study that included patients with stage I extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue or follicular lymphoma of the gastroduodenal region. They were treated with Helicobacter pylori eradication and/or RT between 2000 and 2019 in our institution.

Of the total 79 patients with HbA1c test, 17 patients received RT (RT group), while 62 patients did not receive RT (Control group). A Diabetes-associated event (DAE) was defined as a ≥ 0.5% increase in HbA1c levels from baseline, and diabetes events (DE) were defined as an HbA1c level of ≥ 6.5%.

Key findings of the study include:

During the median follow-up of 49 months, no local failure occurred after RT and no patients died of lymphoma.
The RT group had a significantly higher risk for DAEs on univariable analysis (hazard ratio [HR]=4.18) and multivariable analysis (HR=3.68).
The DE risk was significantly higher in the RT group than in the control group (HR=4.32) and in patients with increased baseline HbA1c levels (HR=35.83).
On multivariable analysis, RT significantly increased the risk of DEs (HR=4.55), even after adjusting baseline HbA1c level (HR=40.97).

"Patients who received RT for gastroduodenal indolent lymphoma had an increased risk of diabetes compared to those who did not," wrote the authors.

Reference:

The study titled, "Increased Risk of Diabetes after Definitive Radiotherapy in Patients with Indolent Gastroduodenal Lymphoma," is published in the journal Cancer Research and Treatment.

DOI: https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2021.073

Cancer Research and Treatmentgastroduodenal indolent lymphomaradiotherapydiabetes

Source : Cancer Research and Treatment

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751