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Recipient of lung transplant dies after receiving COVID-19 infected lungs: Case Report

Medha BaranwalWritten by Medha Baranwal Published On 2021-02-24T20:15:51+05:30  |  Updated On 25 Feb 2021 9:56 AM GMT
Recipient of lung transplant dies after receiving COVID-19 infected lungs: Case Report
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USA: A recent case study describes the case of a woman in Michigan who contracted COVID-19 and died 2 months after receiving a lung transplant from a donor who had COVID-19–infected lungs. The donor had shown no signs of illness and had initially tested negative. The case report is published in the American Journal of Transplantation.In short, D.R. Kaul, Department of...

USA: A recent case study describes the case of a woman in Michigan who contracted COVID-19 and died 2 months after receiving a lung transplant from a donor who had COVID-19–infected lungs. The donor had shown no signs of illness and had initially tested negative. The case report is published in the American Journal of Transplantation.

In short, D.R. Kaul, Department of Internal Medicine, Ann Arbor, MI, USA, and colleagues describe a case of proven transmission of SARS‐CoV‐2 from lung donor to recipient. According to the authors, it is the first proven case of COVID-19 in the U.S. in which the virus was transmitted via an organ transplant. A surgeon who handled the donor lungs was also infected with the virus and fell ill but later recovered.

The donor had no clinical history or findings suggestive of infection with SARS‐CoV‐2 and tested negative by reverse transcriptase polymerase chain reaction (RT‐PCR) on a nasopharyngeal (NP) swab obtained within 48 hours of procurement. Lower respiratory tract testing was not performed.

The recipient developed fever, hypotension and pulmonary infiltrates on post‐transplant day 3, and RT‐PCR testing for SARS‐CoV‐2 on an NP swab specimen was non‐reactive, but positive on bronchoalveolar lavage (BAL) fluid. One thoracic surgeon present during the transplantation procedure developed COVID‐19. Sequence analysis of isolates from donor BAL fluid (obtained at procurement), the recipient, and the infected thoracic surgeon proved donor origin of recipient and health care worker infection. No other organs were procured from this donor

"Transplant centers and organ procurement organizations should perform SARS‐CoV‐2 testing of lower respiratory tract specimens from potential lung donors, and consider enhanced personal protective equipment for health care workers involved in lung procurement and transplantation," wrote the authors.

The case report titled, "Donor To Recipient Transmission Of SARS‐CoV‐2 By Lung Transplantation Despite Negative Donor Upper Respiratory Tract Testing," is published in the American Journal of Transplantation.

DOI: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16532

American Journal of Transplantationlung transplantCOVID 19
Source : American Journal of Transplantation
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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