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  • Vaginal estrogen safe...

Vaginal estrogen safe and effective in women with genitourinary syndrome of menopause with breast cancer

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-05-22T19:15:34+05:30  |  Updated On 22 May 2022 7:15 PM IST
Vaginal estrogen safe and effective  in women with genitourinary syndrome of menopause with breast cancer
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Though vaginal estrogen therapy is safe and effective in women with genitourinary syndrome of menopause (GSM) alongside breast cancer, only a few women use it, according to a recent study published in the Journal of Urology.

Systemic therapies for breast cancer-selective estrogen receptor modulators (SERM), aromatase inhibitors (AI), and chemotherapies - can result in a genitourinary syndrome of menopause (previously recognized as vulvovaginal atrophy) for up to 70% of postmenopausal breast cancer survivors. While systemic estrogen therapy is often avoided in these women, vaginal estrogen can be safely used to treat GSM symptoms. Our objective is to assess the use of vaginal estrogen for women diagnosed with GSM and a personal history of breast cancer using a large US claims database.

The TriNetX Diamond network database was queried: a US health research network of 190 million patients, encompassing healthcare encounters and prescriptions between 2009-2021. Females diagnosed with postmenopausal atrophic vaginitis or atrophy of the vulva (ICD-10 N95.2, N90.5) were included. Of these, women with breast cancer (C50 or Z86.000) were included if the diagnosis was at least 1 month before VVA diagnosis. Estrogen receptor status was collected when available (ICD-10 Z17.0, Z17.1). Prescriptions for treatment of GSM were included if prescribed on the day of VVA diagnosis up to 1 year after index diagnosis. Incidence of vaginal estrogen use in patients with a history of breast cancer was determined for 2013-2015, 2016-2018, and 2019 to the present.

The results of the study are:

A total of 2,159,766 women with GSM were identified, of whom 4.8% (n=104,327) had a personal history of breast cancer. Vaginal estrogen prescriptions were less frequent in women with a history of breast cancer than in women without (11% vs 22%, p<0.01, Table 1). The incidence rate of vaginal estrogen prescriptions for women with GSM and a history of breast cancer remained stable at around 10-11% from 2013 to the present. 25,410 women with GSM and a history of breast cancer had positive estrogen receptor status (ER+), and 4,893 had negative estrogen receptor status (ER-). There was no difference in vaginal estrogen prescribing between ER+ and ER- patients (7.4% vs 8.4%).

Thus, while vaginal estrogen can be safely used in women with GSM and personal history of breast cancer, it is prescribed for few eligible patients. Barriers to the use of vaginal estrogen in this population should be explored to optimize patients' quality of life.

Reference:

Pd44-12 vaginal estrogen therapy for genitourinary syndrome of menopause (gsm) in women with a personal history of breast cancer - a claims database analysis by Kathryn Dumas et al. published in the Journal of Urology

https://doi.org/10.1097/JU.0000000000002605.12



Journal of Urologyvaginal estrogenwomenbreast cancer
Source : Journal of Urology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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